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Difficulty V is considered true end game content and will give even veterans a hard time.

The phrase "Nuke them from orbit" is a well-known line from the 1986 science fiction film "Aliens," directed by James Cameron. In "Aliens," a group of space marines are sent to investigate a colony that has lost contact with Earth. They find the colony overrun by hostile extraterrestrial creatures known as Xenomorphs. The full line from the film is "Nuke the entire site from orbit. It's the only way to be sure." The line is spoken by Ripley when discussing how to deal with the overwhelming threat posed by the Xenomorphs.